FRONTLINE Plus Flea and Tick Spot Treatment for Large Dogs – Waterproof Topical Prevention, 45-88 lbs, 3 Doses

Why This Product Stands Out

FRONTLINE Plus has been the #1 name in flea and tick protection for over 20 years, trusted by millions of pet owners worldwide. This fast-acting, long-lasting topical treatment kills adult fleas, flea eggs, flea larvae, ticks, and chewing lice in a single monthly application. It’s also proven to aid in the control of sarcoptic mange infestations. The waterproof formula starts working within 24 hours of application, giving your dog full protection even after swimming or bathing.

Key Features

• #1 Name in Protection: The most trusted flea and tick brand trusted by pet owners for over 20 years
• Complete Lifecycle Coverage: Kills adult fleas, flea eggs, flea larvae, ticks, and chewing lice
• Fast-Acting Formula: Starts killing fleas within 24 hours of application
• Waterproof Protection: Remains effective even after swimming, bathing, or rain — waterproof within 24 hours
• Full Month of Coverage: A single dose provides continuous protection for 30 days
• Stops Infestations: Breaks the flea life cycle and prevents establishment of new infestations

Design & Quality

Each applicator contains the precise dose needed for large breed dogs weighing 45-88 pounds. The topical formula is applied directly to the skin between the shoulder blades, where it spreads naturally through the skin’s oil glands. Once applied, it continuously releases active ingredients without entering the bloodstream. The three-dose pack provides three full months of protection.

Who It’s For

Essential for large breed dogs (45-88 lbs) who spend time outdoors, visit dog parks, or live in areas with known flea and tick populations. Particularly important during warmer months when fleas and ticks are most active, but year-round protection is recommended in mild climates. Great for hunting dogs, hiking companions, and suburban backyard dogs alike.

Usage Tips

Apply monthly on the same day each month. Part the hair at the base of the neck between the shoulder blades and apply the entire tube directly to the skin. Do not bathe your dog for 24 hours before or after application. For multi-pet households, ensure all pets are on a flea prevention program simultaneously.