Endocrinological Verification

Third-party HPLC testing confirms 12% withanolide glycosides in Sensoril® ashwagandha – 40% higher bioactivity than standard extracts. The 125mg L-theanine dosage achieves peak plasma concentration in 32±8 minutes, synchronizing with cortisol’s diurnal rhythm disruption patterns. In 8-week trials, subjects showed 28% reduction in salivary cortisol upon waking (p<0.01) and 19% improvement in sleep efficiency measured by polysomnography. The vegan cellulose matrix demonstrates 93% dissolution within 45 minutes – critical for nocturnal cortisol surge management.

Adaptogen Efficacy Benchmark

Versus single-ingredient ashwagandha, this formulation accelerates sleep latency reduction by 41% due to L-theanine’s GABA modulation. Compared to synthetic sleep aids, it maintains 89% sleep stage continuity without next-day grogginess (ESS<4). The Sensoril® extract contains 32% more bioactive alkaloids than KSM-66, enhancing HPA axis regulation per Journal of Clinical Endocrinology metrics.

Clinical Protocol

Acute Stress: Take 1 tablet upon waking + 1 tablet 30min before bed during high-stress periods . Chronic Dysregulation: Consistent evening dosing for 6-8 weeks resets cortisol circadian rhythm . Travel Syncing: Combine with 2mg melatonin for jet lag recovery . Adrenal Recovery: Cycle 8 weeks on/4 weeks off for long-term HPA health .

Endocrinologist FAQs

Q: Suitable for shift workers?
A: Yes – take 30min before daytime sleep; avoid caffeine 4hrs prior .

Q: Interaction with SSRIs?
A: No known interactions; consult physician if taking MAO inhibitors .

Q: Morning fatigue risk?
A: 98% users report normal wakefulness when taken ≥8hrs before rising .

Verified Medical Practitioner Review

“After 18 months recommending this to ER physicians with rotating shifts, the 35-year formulation pedigree shows in its consistency. Unlike cheaper ashwagandha blends that cause digestive irritation, the enteric coating prevents gastric discomfort – crucial for our team with high IBS incidence. The real proof came when we tracked salivary cortisol: night shift workers maintained 89% normal diurnal rhythm versus 62% with competing products. Only limitation: requires 3-week continuous use for full effect. For healthcare professionals needing shift-work adaptation without prescription sleep aids, this sets the clinical standard.”

– Dr. Rebecca T. (Emergency Medicine Specialist), Hospital Purchasing Dept